Feb 18th, 2016 Ontology Working Group Meeting

Planteome Ontology WG Zoom Meeting

• Date: Thursday Feb 18th, 2016
• Time: 8:15am PST (GMT-8)
• Connection details: Join from PC, Mac, Linux, iOS or Android: https://zoom.us/j/627445291

• Links to recordings:
  • File:Ontology WG Meeting 2-18-2016 video.mp4
  • File:Ontology WG Meeting 2-18-2016 audio only.m4a

• Attendees: AM, LC, CM, PJ, MAL, EA, GK, JE

Agenda:

Amigo 2.0 issues

1. Display of relations Currently, only the is_a, part_of and occurs_in relations are being displayed

• See Tracker: Relations are not being recognized and displayed in AmiGO 2.0 #20
• CM: its a priority for GO as well and they are working on it, although they have been short-handed, but are making it a priority for Planteome this month.
  • Could browse on OLS-beta: http://www.ebi.ac.uk/ols/beta/ontologies/to (Note that this is only the live version to.owl- cannot view the crop specific ontologies there)
• Timeline: Would like to have this working correctly for the upcoming Release- by middle of March?

• Can we point the OLS and others like Bioportal to 'to-basic.obo'? Looks weird with the BFO and PLANTCHEBIROLE terms.

• The annotations should be moving correctly through the relations in the graph, even if they are not displayed
  • CM: This is why the relations are being filtered. The old AmiGO would propagate everything, but now it can be set in the Planteome AmiGO 2.0 configuration. Generally, you only want the gene expression to propagate up through is_a and part_of

Need to look at the other PO relations such as has_part, participates_in, has_participant and for the TO, inheres_in and occurs_in and any others

2. Display of CO terms with dash or colon. did not discuss this week

• Example: cassava Scale terms: http://dev.planteome.org/amigo/search/ontology

Revisions to the Equivalence Axioms for the TO

• Status of the Biocuration 2016 presentation and possible ICBO paper: Comparison of ontology mapping techniques to map traits (MAL)
  • bottleneck: needs of a collaborative revision of the design patterns (i.e. Equivalence Axioms)

• See: Formal-definitions-in-TO - contains some case information on formal definitions, and uses in trait definitions
• Also Plant Trait Ontology Instances of 'occurs_in'

• Need to clarify when to use occurs_in and when to useinheres_in.

PATO vs. BFO

• BFO wants to use has_number_of to describe count information, and PATO wants to use amount
• BFO- annotate to the larger entity (having a number of)
• PATO - smaller entity has an amount (or towards)
• currently occurs in is used incorrectly towards non-processes.

• PATO has_number_of that inheres in the thing that is being counted. Instead of number_of petals inhering in
  • inheres_in the thing you're counting, occurs_in whatever larger entity

• • quality = amount, entity = seed, occurs_in pod
  • don't use relational qualities (eg: has_number_of)
  • occurs_in == towards

   - amount can inhere in the object being counted, where as has_number_of, is a quality of the larger entity
   - concentration:  has increased concentration in a mixture
     - either increased amount in a mixture
     - has_number_of molecules
     - that's why has-number-of 
     - We should annotate to the upper-level "molecular entity"
       - iron molecular entity
   - being consistent is more important than being correct (ontologically)
   - composition vs. amount
     - composition (PATO) cannot be used for non-morphology things (like blood, or sap)
     - composition is in the structure branch, and should be renamed "structural composition" or "structure composition"

• how to describe "number_of"

• yaml syntax - computable

• • agreement on a timeline

Display of the Crop Ontologies in AmiGO2

• • crop specific names

Visit to IRRI

• Monday March 7th to Friday March 11th
• Goals: TD revision and data annotation- MAL, and Leo will be working on trait dictionary
• Austin- send me the contact info
• all 3 - should be contacting each other as a group

Status of second year funding

• Bioversity is getting impatient, PJ will follow up with NSF and find out