Oct 17th, 2017 Ontology Working Group Meeting

Planteome Ontology WG Zoom Meeting

• Date: Tuesday Oct 17th, 2017
• Time: 8:15am PDT (GMT-7)

• Connection details:

Topic: Planteome Ontology WG Meeting Time: Oct 17, 2017 8:15 AM Pacific Time (US and Canada)

Join from PC, Mac, Linux, iOS or Android: https://zoom.us/j/609630127

• Meeting Recordings:
  • File:Ontology WG meeting 10-17-17 audio only.m4a
  • File:Ontology WG meeting video 10-17-17.mp4

Agenda and Notes

== Visit to BTI at Cornell next week- LC and MAL will attend

• MAL:
  • RTB Program of CGIAR crops: root, tuber and banana- also includes cassava, sweet potato, potato, and yam
  • Fieldbook, need be able to add new traits and variables
  • Afola (cassava) would prefer to update the OBO or OWL file
  • Curators for banana, sweet potato, potato, yam would prefer to edit the TD- who is it?
  • Goal is to set up the synchronization between CO and GitHub, Need to be trained on Protege to update the file
  • Show Planteome and the mappings to the TO
  • TD related questions, find out what data is available
  • Breeding API- being widely implemented
  • Will work on get data for each crop, if available

• EA:
  • These are important 2017 Deliverables for RTB project:
  • Breeding Community of Practice (CoP) includes all the RTB crops
  • Breeding Super Products, for breeding align the BTI next-gen database for those crops, with the Breeding Management System (BMS)
  • Goal: everyone using the same workflows, variables, fieldbook etc
  • Breeding API- being widely implemented- http://docs.brapi.apiary.io/#

• PJ:
  • Are we generating a species-specific ontology graphs for each crop, with the upper TO hierarchy?
  • We should be creating one for each crop with species-specific tree
  • MAL: This can be easily done, hierarchy from the TO can be created in the Protege, each class is a subclass of the TO terms
  • This allows the curators to just maintain the TD and ref ontology tree can guide then
  • When the CO is converted to OBO file to do the mapping, it is a flat list, so the hierarchy is coming from the TO
  • Planteome APIs can also serve the CO terms, so they should be using them rather than APIs from multiple other sources
  • PJ will send an email about what he would like to see

• Can we access some publicly available data on the RTB crops?

- Annotated and cleaned data, not the raw data from the breeding programs - would like to get some for each of the crops- good example for TO paper - annotations are also served through the APIs

Paper for mapping and improvements to the TO

Marie will lead with LC (co-first authors?) Details of the methods of mapping, peer-reviewed Short and sweet paper on the initial 8-10 crops - perhaps for Current Plant Biology (now on PubMed) EA: Marie needs to have a paper, focus on the mapping…. PJ: include discussions at BTI, about how the planteome is fostering the community standards, encouraging the community to adopt them and utilizing the datasets and keeping the ontologies up to date Include revisions to TO and update Also cover the design patterns

CM: what is the focus of the mapping paper, plant crop folks or bioinformatics people? PJ: Should be both, go into a plant journal, get community involvement, LC and MAL will be in Cornell next week, working with Lukas Mueller’s group, banana and tuber crops, Designing workflow for annotation and data collection

4. Second paper including the Samara work: CM, AM, LC with MAL- discussions with the consultant Jorrit- see the gdoc: Planteome Term Matcher AM has an email from Jorrit - asked him to share it with the group, or at least me Mapping the trait descriptors to the TO, sort of overlaps with what Marie has been doing, so we need to sort that out Also covers the design patterns

Newly published paper by the WDI in F1000Research: https://f1000research.com/articles/6-1843/v1

Barry Smith- no updates

Redoing the genome GO annotations for next release of the Planteome: Get new proteome files and redo GO annotations Gramene and PlantEnsemble are updating their genome and are out of sync with Uniprot, so would be better to get from Planteome We should be the primary annotator for GO annotations for plants. We should be sharing GO annotations into GOC, the UniProt would pick up- only GO annotations (not PO, TO etc), also Plant Ensemble, Gramene and Plant Reactome- all would be in sync Projections from Arabidopsis to other species- need to use something like taxon restraints to ensure that annotations are not projected in error PJ, JE, AM- rechecking work flow for rice, adding semi-automated pipeline Add confidence scores, transmembrane domains, chloroplast proteins, not utilized right now Will move to doing it on all 65 species, Projection from Arabidopsis

Primary resource for the public editing interface being developed with private company which has been contracted. Building database, registered users can edit, take responsibility of certain genes etc

Running: Interproscan, THMM, TargetP etc rice is test case Inparanoid result, for projections Will feed back filtered set of GO annotations into the GO database

GO’s QC pipeline should be integrated into the pipeline- Eric and Seth Should be run at CyVerse Show on next meeting- Oct 31st

CM: New tool: Jenkins 2 for QC can be run, publishes report Jenkins 2 demonstration at next meeting- Oct 31st Annotations at GOA from Uniprot- Protein2GO

PJ: Maize GO annotations from MaizeGDB - from Lisa H? - https://github.com/Planteome/planteome-annotation-data/issues/1

PJ: Renewal plan- submit by spring

TO DO: Create folders for Planteome papers: TO paper with mapping to CO vocabs

Samara papers- see: https://docs.google.com/document/d/1p5PUqXnPQWlFYKHH5yJtbPpRcOnX0AsuGRj7M_2HxAk/edit One paper on GRIN annotations, one on the stress ontology….?

Renewal- community engagement, data analysis for community, biological focus, machine learning, smaller scale proposal, emphasis on data reuse, standards, not so much on ontology development, biology driven rather than resource driven Need to focus by biological questions: eg. plant traits link to env factors and some plant genes, use the APIs, What can the users get from the resource, machine learning Submit by spring, PGP may not exist

High Throughput phenotyping talks on future calls EA will contact Pascal, Francois

MAL visit to Corvallis? AM could use help with stress ontology, etc for the release PJ agreed, could also get CM to come or go to Berkeley When? Who will pay the travel costs?

Phenoscape Hackathon in Dec: https://blog.phenoscape.org/ CM and LC, JE, AM may attend, what other plant people going- who? Maybe Hilmar could come on a future call and show us an overview? Experimental plant phenoscape- what is plant community looking for Can we get a list of the attendees?

Items from the NAR Review: Chris Mungall: https://github.com/Planteome/biolink-api/issues/3

Need to update the Planteome website-

Upcoming Events

• Phenoscape Hackathon in Dec

• Plant and Animal Genome meeting January 2018